Tag: antifungal efficacy
Proton Pump Inhibitors and Antifungals: How They Interfere with Absorption and Effectiveness
Proton pump inhibitors can severely reduce absorption of certain antifungals like itraconazole and ketoconazole, leading to treatment failure. Fluconazole is unaffected by stomach pH but interacts with other drugs. Emerging research shows PPIs may also boost antifungal effectiveness against resistant fungi.