Endep Dosage Guide – How to Take Endep Safely

If you’ve been prescribed Endep (amitriptyline), the first thing you want to know is how much to take. The right dose can control your symptoms while keeping side effects low. Below you’ll find the most common dosing ranges, how doctors decide the right amount, and practical tips for adjusting it if needed.

Standard Dosage for Different Conditions

Endep is used for depression, chronic pain, migraine prevention, and some sleep problems. For adults with depression, doctors usually start at 25 mg at bedtime and raise it by 25 mg every week. Most people end up between 75 mg and 150 mg daily, split into one dose at night. For chronic pain or migraines, the starting dose is often lower—10 mg to 25 mg at night—and the target range can be 25 mg to 100 mg, depending on response.

Seniors or people with liver issues may need a slower climb. Doctors might begin at 10 mg and increase by just 10 mg every two weeks. The goal is the same: find the lowest dose that works.

Tips for Adjusting Your Dose

When you first start Endep, give it at least a week before deciding it’s not working. The medication builds up in your system, so you might not feel full benefit right away. If you notice drowsiness, try taking it an hour earlier or with a light snack.

If side effects like dry mouth or constipation become bothersome, talk to your doctor before cutting the dose. Sometimes a small reduction—5 mg or 10 mg—helps a lot without losing the therapeutic effect.

Never skip a dose to “reset” the medication. Skipping can cause a sudden drop in blood levels and may trigger withdrawal symptoms. If you miss a dose, take it as soon as you remember unless it’s almost time for the next one—then just skip the missed one.

Keep a simple log: note the dose, the time you take it, and any new symptoms. This log makes it easier for your doctor to fine‑tune the dose during follow‑up visits.

When you’re ready to stop Endep, taper slowly. A typical taper might drop 10 mg every two weeks. Going too fast can cause rebound depression or other withdrawal signs.

Remember, everyone’s response is unique. The numbers above are common starting points, but your doctor will tailor the plan to your health, age, and how you feel. If you ever feel dizzy, heart palpitations, or severe mood changes, seek medical help right away.

Bottom line: start low, increase slowly, and keep track of how you feel. With the right dose, Endep can be a helpful tool for managing mood, pain, or sleep, while keeping unwanted side effects in check.